Professor Ronnie Chowdhury will delve into the realm of cyber-physical-social systems (CPSS) and their multifaceted aspects for future infrastructures and multimodal mobility. Through CPSS, we seamlessly integrate sensing, communication, computation, and users across various cyber, physical, and social systems. Within a CPSS environment, these components communicate with one another to achieve specific objectives. Today, CPSS are omnipresent, spanning from smart home devices to complex grid systems, connected and automated transportation systems, logistics, and even extending to extraterrestrial outposts such as space stations. The interconnected nature of CPSS, however, introduces a myriad of vulnerabilities, unraveling potential attack surfaces by malicious actors. These threats can rapidly propagate across different interconnected CPSS, leading to widespread disruptions at local, state, or national levels. This talk will reflect upon diverse CPSS applications and their effectiveness for multimodal connected and autonomous mobility, drawing from the ongoing research projects conducted by Ronnie and his team. Additionally, he will spotlight his group’s endeavors in CPSS security, focusing on innovative approaches to detect and mitigate cyberattacks on software and hardware, and resiliency against such attacks.